HIV clinical trials
Clinical trials help to answer important questions and allow us to make treatment and care better.
For independent advice on taking part in an HIV study, see the i-base website www.i-base.info/ or call their treatment phoneline 0808 800 6013 (Mon-Wed 12 noon-4pm). We currently have the following clinical trials open:
GEMINI 2 This is a drug trial for people who haven't taken HIV treatment before. All the drugs used in this study are already being used. Everybody in this trial gets two tablets to take each day.
DISCOVER (PrEP study) A study for men who have sex with men or transgender women who are at risk of HIV infection, and comparing two different tablets to reduce the risks of acquiring HIV infection.
SUPA This study is for people starting treatment for the first time. It is not a drug trial but is looking at how best we can support people who are new to taking treatment. More information
START This is looking at people with a CD4 count greater than 500 – at this level we wouldn't normally suggest starting HIV treatment. This study involves putting people on standard treatment versus monitoring them and starting treatment later as usual, to see if earlier treatment is helpful. People in this study have additional monitoring, including heart and lung testing. Results
SINGLE This study is looking at a new drug called an integrase inhibitor, plus another tablet called Kivexa, versus our standard starting treatment, to see how they compare. As in most studies, we are not allowed to decide which treatment a patient gets, as this would make the results less useful. Results
SAILING This looks at a new integrase inhibitor versus an established drug called raltegravir, given together with whatever medications your doctor thinks would work. We are looking for patients whose current treatment isn't working, and who have resistance to at least 2 types of HIV medications. Results
GS-EU-236-0141 This looks at the results of routine kidney monitoring tests for people receiving a single tablet combination called Stribild. Closed
BESTT This is a study for women who are stable on HIV treatment to see if changing to a single tablet combination has an effect on the bones.
GS-US-311-1717 This is offered to people who are currently on a combination including the drug Kivexa (lamivudine/abacavir) and looks at changing people to an alternative treatment with some extra kidney and bone monitoring tests.
MK-1439-018 This is looking at a new drug which is part of a family of drugs called non-nucleoside reverse transcriptase inhibitors (NNRTIs). It is given with a choice of other medications, and is being compared to a combination which we already use. This is for people starting treatment for the first time.
UK STIGMA INDEX This is a survey open to all people living with HIV, and it can be done either in the clinic or at home Closed
POSITIVE VOICES STUDY This is a confidential survey around experiences of being HIV positive which you can complete on a tablet in the clinic during your visit, or at home.
The UK Collaborative HIV Cohort (UK CHIC) Study This investigates the clinical outcomes, response to treatment and epidemic dynamics of HIV-1 in the UK. This is a collaboration that started in 2001 to put together data relating to clinical care and treatment of HIV. The study database contains routinely collected and anonymous clinical information on HIV positive individuals aged over 16 years who have attended certain clinics for care at any time in 1996 or thereafter. Currently, the database contains more than 34,000 records of patients who have attended for care at one of a number of HIV clinics around the UK. The purpose of the study is to analyse the data to monitor the uptake and response to therapy among individuals with HIV in the UK. For more information visit http://www.ukchic.org.uk/
PRIME STUDY This is a study for HIV positive women aged 40-60 who are still having their periods, or who have had their periods stop in the last five years. It involves completing a booklet of questions around symptoms that we sometimes see in women of this age. Closed
If you are interested in taking part in a clinical trial or want more information, ask your doctor, nurse or pharmacist.